Abstract
Organoids are generated from the stem cells through in-vitro three-dimensional culture that can imitate the structure as well as the functions of any particular tissue or organ in-vivo. This modern technology has sprung up during the past decades and has become one of the most popular technologies among researchers. Of late, there are several different kinds of 3-D organoid culture approaches available, each having specific benefits and challenges. Tumor organoids are specially cultivated for cancer treatment because they can preserve features of the original tumors. Though it is not well understood about the genesis of organoids and how they have been used in cancer treatment, but recently a number of researchers have confirmed that organoids have tremendous potential in the field of clinical research for drug development, drug screening, precision therapy, etc. through their studies. In this review article, we precisely reviewed the brief history of organoids, the cultivation processes of different tumor organoids, their potential applications, current limitations, and future prospects. Recent studies have demonstrated that the combination of organoids and some other technologies (Artificial Intelligence, gene editing tools, etc.) would be able to imitate the tumor microenvironment, which could develop new horizons in the field of cancer research in the future.
Keywords: Cancer, Drug Screening, Organoid, Organoid Cultivation, Tumor.