Abstract The COVID-19 pandemic has posed a menace to human life worldwide. This has triggered the thrust for the develop-ment of effective therapeutics and vaccines based on varied strategies. The trend for the repurposing of approved molecules or those already in the clinical stage of development for other indications has been currently explored to facilitate […]
The Current Therapeutic and Vaccine Pipeline of COVID-19 Read More »
Abstract Cancer is among the leading causes of death worldwide. The key therapeutic modalities to treat cancer include chemo-therapy, hormonal therapy, targeted therapy, immuno-therapy and combination therapy. A number of chemical agents target DNA; they cause breaks, intercalation and cross-links to damage DNA thereby inhibiting cell proliferation. Cisplatin and taxol based chemotherapies are still the
Abstract Recent COVID-19 pandemic has caused the greatest crisis in human civilisation worldwide. Initially started in Wuhan, China it has gradually spread all over the world due to the time taken by the people to understand the seriousness of the disease. Initial symptoms are unremarkable and typical of upper respiratory tract viral infection, followed by
The COVID-19 Pandemic Read More »
Abstract Ribosomes are large ribonucleoprotein complexes that have been proved to be ideal biological sample for the development of the cryo-Electron Microscopy (cryo-EM) field. On the other hand, advancement in cryo-EM technologies have helped in elucidating detailed structure-function aspects of various kinds of ribosomes, belonging to prokaryotic, organellar, and complex eukaryotic systems. In a relatively
Resolution Revolutions on the Cryo-EM Structures of Ribosome- A Study: 1981-2018 Read More »
Abstract The Erythrocyte Binding Ligand (EBL) is an important protein of Plasmodium sp. required by the parasite for successful invasion into the red blood cells causing malaria. EBL is a potential anti-malarial drug target. Despite its importance only a portion of its structure i.e., Duffy Binding Domain (DBD), is solved. Thus, the remaining regions necessitate
Abstract Mother-child bonding is not confined to human beings, rather all living animals show baby love. It is quite interesting to intervene in the mechanisms or causative factors of this affection and its consequences. In this article, we attempt to delineate that the chemical factors could be responsible for the affection or aggressiveness which ultimately
