Abstract
Snail mucus is gaining significant attention as a natural biomaterial for wound repair and regenerative medicine. This review focuses on the biomedical potentials of two key proteins found in snail mucus-Achacin and Mytimacin-AFhighlighting their antimicrobial, anti-inflammatory, and tissue-regenerative properties. A systematic literature search was conducted across major databases (2013–2025), selecting studies that examined the roles of snail mucus proteins in wound repair, antimicrobial defense, angiogenesis, and tissue regeneration. Mytimacin-AF is a cysteine-rich peptide, and Achacin is a glycoprotein with L-amino acid oxidase activity. They both work against a wide range of bacteria and fungi, help release cytokines, and get more immune cells to the area. Preclinical study shows that snail mucus can improve the quality of scars, speed up wound closure by 24–37%, and increase angiogenesis and collagen deposition compared to standard treatments. These proteins help both new and old wounds heal faster by increasing the number of fibroblasts, changing the extracellular matrix, and keeping the body’s inflammatory reactions in check. It is still hard to make sure that all snail species have the same makeup, describe changes that happen after translation, and standardise extraction methods, further study should focus on clinical trials, detailed molecular characterisation, and new ways to deliver the proteins.
Keywords: Achacin, Antimicrobial Peptides, Mytimacin-AF, Snail Mucus, Tissue Regeneration, Wound Healing