Coumarin Chalcone Hybrids: Molecular Hybridization Strategy for Drug Design

Naturally occurring and synthetically produced hybrid compounds are potential reservoir for development of novel drug regimen because of various benefits including effectiveness, minimal side effects, receptor interactions and pharmacokinetic features. Coumarin and chalcone are perfect building blocks for creating hybrid scaffolds that can be used as bioactive agents. These are essential classes of synthetic chemistry with wide range of pharmacological properties. Encouraged by potential therapeutic and medicinal significance of these hybrids, the scientists have reported dozens of coumarin chalcone hybrids with a broad range of biological properties like antioxidant, analgesic, antimicrobial, antiviral, anticancer, antianxiety, antimalarial, anti-inflammatory etc. It is intended to support to medicinal researchers in the efficient, fruitful development of coumarin chalcone hybrids to maximize their biological potential. In view of these findings, we present here some literature review, synthetic methods and pharmacological efficacy, molecular targets.