ABSTRACT
Background: Psoriasis is a common chronic inflammatory skin disorder associated with multiple comorbidities and significant effect in quality of life. Multiple comorbidities including disorders of lipid and lipoprotein, oxidative stress as well as metabolic syndrome has been found to be associated with psoriasis. There are several researches on lipid profile and psoriasis but the result is not consistent.
Objective: To determine the lipid profile in patients with psoriasis and to compare it with healthy controls and to determine relation between lipid abnormalities and duration of disease & severity of psoriasis (graded by Psoriasis Area Severity Index, PASI).
Methods: A comparative cross-sectional study was conducted among 71 cases and 71 control from 1st Oct 2019 to 31st Sep 2020 in the Department of Dermatology and Venereology, Koshi Hospital, biratnagar, Nepal to compare the lipid profile among patients with psoriasis and healthy controls.
Result: Serum Total Cholesterol and Low-Density Lipoprotein Cholesterol was significantly higher in patient with psoriasis as compared to control (165.65± 36.18 vs 147.90±32.84, p<0.001). A significant correlation was observed between severity of disease measured by PASI and TC (r=0.274, p=0.021) and LDL-Cholesterol (r=0.248, p=0.037).
Conclusion: Patients with psoriasis have significantly high lipid abnormalities in terms of increased total cholesterol and LDL cholesterol. Dyslipidemias found in them paralleled with disease severity and durations. Early screening and treatment of hyperlipidemia in patients with psoriasis is advised to prevent atherosclerosis and its complications in them.
Key words: Dyslipidemia, PASI, lipid profile, Psoriasis.