journals

Transcriptomic Insight and Structural Integration: Repositioning FDA-Approved Methotrexate Derivative for Precision Therapy in Lung Cancer through Drug-Drug Similarity Analysis and Cavity-Guided Blind Docking

Author(s): Harshal Tare*, Vaishali Vaidya, Swati Fulmali, Sayali Jadhao, Mayuri Wankhade, Manish Bhise
Volume: 5 Issue: 1 Pages: 631-639
DOI: https://doi.org/10.47857/irjms.2024.v05i01.0300


Abstract In the pursuit of advancing precision therapy for lung cancer, this study explores the repositioning potential of a FDA approved methotrexate derivative, with a specific focus on its interaction with the Dihydrofolate Reductase (DHFR) enzyme. Leveraging transcriptomic insights and structural integration, our research employs a multifaceted approach, encompassing drug-drug similarity analysis and cavity-guided blind […]

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Development of Brief Machiavellianism Scale (BMS-06)

Author(s): Sandeep*, Tajbina Yasin, Rohit Kumar Maurya
Volume: 5 Issue: 1 Pages: 621-630
DOI: https://doi.org/10.47857/irjms.2024.v05i01.0291


Abstract The purpose of this study was to develop an indigenous brief scale of Machiavellianism among working population. Initially, a pool of 70 items was generated which was formed through focused discussion with a group of some randomly working people. Furthermore, their verbatim was compiled and phrases and with that three domains were formed. Again,

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HRM Practices and Knowledge Sharing in IT Sector – A Study in Coimbatore, Tamil Nadu

Author(s): Saravanabhavan N*, Subashini R, Velmurugan G
Volume: 5 Issue: 1 Pages: 607-620
DOI: https://doi.org/10.47857/irjms.2024.v05i01.0289


Abstract Knowledge sharing is one of the contemporary and emerging HRM topics that has attracted much research; it is one of the stages of competence management, which is considered a valuable working tool in the company and strategy. The main objective of this study is to examine the relationships between human resource management (HRM) practices

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Lane Departure Analysis: Bibliometric Methods and Trends

Author(s): Vidya Sagar SD*, Prabhakar CJ
Volume: 5 Issue: 1 Pages: 593-606
DOI: https://doi.org/10.47857/irjms.2024.v05i01.0283


Abstract The present study employs the VOS Viewer software to conduct a bibliometric analysis on lane departure research. 1424 articles from the Scopus core database spanning 1968 to 2023 were analyzed. This study aims to comprehensively examine the progression, trends, and key contributors in lane departure research. The methodology employed in this study encompasses a

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A New Method for Improving the Performance of Domestic Utilities by Balancing Energy Generation and Peak Demand Using Ebola Optimization Technique

Author(s): Nandish BM*, Pushparajesh V
Volume: 5 Issue: 1 Pages: 582-592
DOI: https://doi.org/10.47857/irjms.2024.v05i01.0281


Abstract As the global energy market is growing rapidly, global warming and concern towards the energy crisis is an issue to address in the modern energy market. Addressing these issues by balancing the peak power shifting on real time in micro grids. This paper discusses about an intelligent multi-agent-based system, which allows the user to

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An Improved Red Panda Optimizer for Effective Construction Site Design

Author(s): Malathy N*, Sathya K, Baskaran P, Somasundaram SK
Volume: 5 Issue: 1 Pages: 568-581
DOI: https://doi.org/10.47857/irjms.2024.v05i01.0274


Abstract A properly planned design will minimize travel distance, handling of materials diligence, and operating costs, as well as saving time and ease site congestion. The majority of mathematical optimization approaches discovered thus far are effective for modest problems and frequently fall within global or local optimum solutions, which does not ensure continued convergence. As

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Privacy-Preserving Medical Diagnosis System Using Harris Hawk Optimization in Edge Computing

Author(s): Malathy N*, Grace Sophia J, Swathi S, Vijaya Subasri K
Volume: 5 Issue: 1 Pages: 157-170
DOI: https://doi.org/10.47857/irjms.2024.v05i01.0182


Abstract With the enhancement of artificial intelligence and machine learning, nowadays it is in trend that mobile clients acquiesce their sign for diagnosing medical illnesses. Edge computing methodology is frequently used for medical diagnosis as it reduces the transmission latency and allows users and devices even at remote locations to analyze the data at the

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The Influence of Emotional Intelligence in the Choice of Conflict Resolution Strategy

Author(s): Fleura Shkëmbi*, Valbona Treska
Volume: 5 Issue: 1 Pages: 144-156
DOI: https://doi.org/10.47857/irjms.2024.v05i01.0181


Abstract The purpose of this article is to examine the need for Emotional Intelligence (EI) in conflict resolution and the workplace. Based on the review of emotional intelligence models, we aimed to comprehend the ability to resolve the effect of conflict and the process of regulation and processing of conflicts. Data was collected from 280

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Communication Activities with Indigenous Content for Enhancing Speaking Skills of Undergraduate Students in ESL Classroom

Author(s): Dinesh Kumar S*, Barathi S, Aravind BR, Pradeepa K, Gnanaraj S, Sasi Devi D
Volume: 5 Issue: 1 Pages: 134-143
DOI: https://doi.org/10.47857/irjms.2024.v05i01.0179


Abstract This paper aims to study and equate the oral or verbal ability of the second-year students of B.Sc., Physics and Mathematics courses of Thiagarajar College, Madurai, by using three communication activities with indigenous content and also to analyze the learners’ attitude during the period. The students are exposed to a learner-centered classroom that demands

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Enablers and Outcomes of Supply Chain Collaboration for Sustainable Growth

Author(s): Suganya G, J Joshua Selvakumar, Sathish Pachiyappan*
Volume: 5 Issue: 1 Pages: 535-556
DOI: https://doi.org/10.47857/irjms.2024.v05i01.0264


Abstract This study explores the intricate dynamics, challenges, and potential benefits of supply chain collaboration, emphasizing its pivotal role in achieving sustainability goals. Modern Supply Chain Collaboration (SCC) projects focus on sustainability-related activities, fostering interdependence between partners and driving sustained competitive advantage. The study introduces a comprehensive framework encompassing specific enablers (e.g., Joint Decision Making,

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